Identification of biomarkers for obsessive-compulsive disorder in lymphoblastoid cell lines

Contact person

Prof. Dr. Edna Grünblatt
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital
University of Zürich
edna.gruenblatt@kjpd.uzh.ch

Prof. Susanne Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital
University of Zürich
susanne.walitza@puk.zh.ch

Duration

Since October 2015 - Ongoing

Project

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder and the lack of peripheral biomarkers for personalized medicine to date makes the treatment process to be much more complex with need of improvements. In the current project the effect of selective serotonin reuptake inhibitors (SSRIs) on downstream molecular targets in lymphoblastoid cell lines isolated from OCD patients and healthy controls is determined. In addition, the expression levels and activity of molecules affected by the serotonergic system in lymphoblastoid cell lines of OCD patients and healthy controls is studied. The aim of the project is to aid the identification of peripheral biomarkers for OCD, particularly in children and adolescents.

Financing

Olga Mayenfisch Foundation