Gene variants association and epigenetic mechanisms with ADHD in family and case-controls

Contact person

Prof. Susanne Walitza

Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital
University of Zürich

susanne.walitza@puk.zh.ch

Prof. Dr. Edna Grünblatt

Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital
University of Zürich

edna.gruenblatt@kjpd.uzh.ch

Duration

01.08.2016 - on going

Summary

Attention-deficit/hyperactivity disorder (ADHD) is a common behavioral disorder with a high heritability of up to 80% according to family and twin studies. A wide range of studies investigated candidate genes involved in the dopaminergic, noradrenergic and serotonergic neurotransmission system without conclusive results. This project focusses on various candidate genes (e.g. the serotonin- (SERT; SLC6A4), the dopamine-transporter (DAT1, SLC6A3)) and combines these results with possible epigenetic effects (like.g. CpG methylation levels) involved in the pathogenetic mechanism for ADHD.