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Kinder- und Jugendpsychiatrie und Psychotherapie (KJPP)



Preprint:  Haugg, A., Frei, N., Lutz, C., Di Pietro, S. V., Karipidis, I. I., & Brem, S. (2023). The structural covariance of reading-related brain regions in adults and children with typical reading skills and developmental dyslexia

Preprint:  Cha, J., Kim, B., Kim, G., Thompson, P., Bruin, W., Gv, W., ... & Zhao, Q. (2023). White matter diffusion estimates in obsessive-compulsive disorder across 1,653 individuals: Machine learning findings from the ENIGMA OCD Working Group.

Bertolín, S., Alonso, P., Martínez-Zalacaín, I., Menchón, J. M., Jimenez-Murcia, S., Baker, J. T., ... & Soriano-Mas, C. (2023). Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 62(4), 403-414.

Bruin, W. B., Abe, Y., Alonso, P., Anticevic, A., Backhausen, L. L., Balachander, S., ... & van Wingen, G. A. (2023). The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium. Molecular Psychiatry, 1-13.

Di Pietro, S. V., Willinger, D., Frei, N., Lutz, C., Coraj, S., Schneider, C., ... & Brem, S. (2023). Disentangling influences of dyslexia, development, and reading experience on effective brain connectivity in children. NeuroImage, 268, 119869.

Di Pietro, S. V., Karipidis, I. I., Pleisch, G., & Brem, S. (2023). Neurodevelopmental trajectories of letter and speech sound processing from preschool to the end of elementary school. Developmental Cognitive Neuroscience, 61, 101255.

Haugg, A., Frei, N., Menghini, M., Stutz, F., Steinegger, S., Röthlisberger, M., & Brem, S. (2023). Self-regulation of visual word form area activation with real-time fMRI neurofeedback. Scientific Reports, 13(1), 9195.


Fraga-González G, Di Pietro SV, Pleisch G, Walitza S, Brandeis D, Karipidis II, Brem S (2022). Visual Occipito-Temporal N1 Sensitivity to Digits Across Elementary School. Frontiers in Human Neuroscience. 2022 Jul 26.

Richie-Halford A, Cieslak M, Ai L, Caffarra S, Covitz S, Franco AR, Karipidis II, Kruper J, Milham M, Avelar-Pereira B, Roy E, Sydnor VJ, Yeatman JD; Fibr Community Science Consortium, Satterthwaite TD, Rokem A (2022).Publisher Correction: An analysis-ready and quality controlled resource for pediatric brain white-matter research. Scientific Data. 2022 Oct 31;9(1):665.

Richie-Halford A, Cieslak M, Ai L, Caffarra S, Covitz S, Franco AR, Karipidis II, Kruper J, Milham M, Avelar-Pereira B, Roy E, Sydnor VJ, Yeatman JD; Fibr Community Science Consortium, Satterthwaite TD, Rokem A (2022). An analysis-ready and quality controlled resource for pediatric brain white-matter research. Scientific Data. 2022 Oct 12;9(1):616.

Zhang M., Riecke L., Fraga-González G., Bonte M. (2022). Altered brain network topology during speech tracking in developmental dyslexia. Neuroimage, Vol. 254. Epub ahead of print.

Willinger D., Karipidis I. I., Häberling I, Berger G., Walitza S., Brem S. (2022). Deficient prefrontal-amygdalar connectivity underlies inefficient face processing in adolescent major depressive disorder. Translational Psychiatry, Vol. 12(195).

Patel Y., Shin J., Abé C., Agartz I., Alloza C., Alnæs D., …, Willinger D., Winter A., …, Paus T. (2022). Virtual Ontogeny of Cortical Growth Preceding Mental Illness. Biol Psychiatry. Biological Psychiatry, Vol. 92(3). Epub ahead of print.

Liu Y., Chen Y., Fraga-González G., Szpak V., Laverman J., Wiers R. W., Richard Ridderinkhof K. (2022). Resting-state EEG, Substance use and Abstinence After Chronic use: A Systematic Review. Clinical EEG and Neuroscience 2022, Vol. 53(4) 344–366.

Duerler, P., Brem, S., Fraga-González, G., Neef, T., Allen, M., Zeidman, P., Stämpfli, P., Vollenweider, F. X., & Preller, K. H. (2022). Psilocybin Induces Aberrant Prediction Error Processing of Tactile Mismatch Responses-A Simultaneous EEG-FMRI Study. Cerebral cortex, 32(1), 186–196.

Kong, X. Z., ENIGMA Laterality Working Group, & Francks, C. (2022). Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research. Human brain mapping, 43(1), 244–254.

Hoogman, M., van Rooij, D., Klein, M., Boedhoe, P., Ilioska, I., Li, T., Patel, Y., Postema, M. C., Zhang-James, Y., Anagnostou, E., Arango, C., Auzias, G., Banaschewski, T., Bau, C., Behrmann, M., Bellgrove, M. A., Brandeis, D., Brem, S., Busatto, G. F., Calderoni, S., … Franke, B. (2022). Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure. Human brain mapping, 43(1), 37–55.

Van den Heuvel, O. A., Boedhoe, P. S., Bertolin, S., Bruin, W. B., Francks, C., Ivanov, I., ... & Yamada, K. (2022). An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration. Human Brain Mapping, 43(1), 23-36.



Ovalle-Fresa, R., Di Pietro, S. V., Reber, T. P., Balbi, E., & Rothen, N. (2021). Standardized database of 400 complex abstract fractals. Behavior Research Methods, 1-16.

Fraga-González, G., Smit, D., Van der Molen, M., Tijms, J., Stam, C. J., de Geus, E., & Van der Molen, M. W. (2021). Graph Analysis of EEG Functional Connectivity Networks During a Letter-Speech Sound Binding Task in Adult Dyslexics. Frontiers in psychology, 12, 767839. 

Karipidis, I. I., Pleisch, G., Di Pietro, S. V., Fraga-González, G., & Brem, S. (2021). Developmental Trajectories of Letter and Speech Sound Integration During Reading Acquisition. Frontiers in psychology, 12, 750491.

Li, T., van Rooij, D., Roth Mota, N., Buitelaar, J. K., ENIGMA ADHD Working Group, Hoogman, M., Arias Vasquez, A., & Franke, B. (2021). Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes. Journal of child psychology and psychiatry, and allied disciplines, 62(9), 1140–1149.

Willinger, D., Karipidis, I. I., Dimanova, P., Walitza, S., & Brem, S. (2021). Neurodevelopment of the incentive network facilitates motivated behaviour from adolescence to adulthood. NeuroImage, 237, 118186.

Werhahn, J. E., Mohl, S., Willinger, D., Smigielski, L., Roth, A., Hofstetter, C., Stämpfli, P., Naaijen, J., Mulder, L. M., Glennon, J. C., Hoekstra, P. J., Dietrich, A., Kleine Deters, R., Aggensteiner, P. M., Holz, N. E., Baumeister, S., Banaschewski, T., Saam, M. C., Schulze, U., Lythgoe, D. J., … Brandeis, D. (2021). Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior. European child & adolescent psychiatry, 30(8), 1237–1249. 

Willinger, D., Karipidis, I. I., Neuer, S., Emery, S., Rauch, C., Häberling, I., Berger, G., Walitza, S., & Brem, S. (2021). Maladaptive Avoidance Learning in the Orbitofrontal Cortex in Adolescents With Major Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021 Jun 16; S2451-9022(21)00167-1.

Fraga-González, G., Pleisch, G., Di Pietro, S. V., Neuenschwander, J., Walitza, S., Brandeis, D., Karipidis, I. I., & Brem, S. (2021). The rise and fall of rapid occipito-temporal sensitivity to letters: Transient specialization through elementary school. Developmental cognitive neuroscience, 49, 100958.

Postema, M. C., Hoogman, M., Ambrosino, S., Asherson, P., Banaschewski, T., Bandeira, C. E., Baranov, A., Bau, C., Baumeister, S., Baur-Streubel, R., Bellgrove, M. A., Biederman, J., Bralten, J., Brandeis, D., Brem, S., Buitelaar, J. K., Busatto, G. F., Castellanos, F. X., Cercignani, M., Chaim-Avancini, T. M., … Francks, C. (2021). Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. Journal of child psychology and psychiatry, and allied disciplines, 62(10), 1202–1219.  

Piras, F., Piras, F., Abe, Y., Agarwal, S. M., Anticevic, A., Ameis, S., Arnold, P., Banaj, N., Bargalló, N., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Boedhoe, P., Bollettini, I., Brem, S., Calvo, A., Cho, K., Ciullo, V., Dallaspezia, S., Dickie, E., … Spalletta, G. (2021). White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group. Translational psychiatry, 11(1), 173.

Chyl, K., Fraga-González, G., Brem, S., & Jednoróg, K. (2021). Brain dynamics of (a)typical reading development-a review of longitudinal studies. NPJ science of learning, 6(1), 4.

Zhang-James, Y., Helminen, E. C., Liu, J., ENIGMA-ADHD Working Group, Franke, B., Hoogman, M., & Faraone, S. V. (2021). Evidence for similar structural brain anomalies in youth and adult attention-deficit/hyperactivity disorder: a machine learning analysis. Translational psychiatry, 11(1), 82. 



Brem, S., Maurer, U., Kronbichler, M., Schurz, M., Richlan, F., Blau, V., ... & Brandeis, D. (2020). Visual word form processing deficits driven by severity of reading impairments in children with developmental dyslexia. Scientific Reports, 10(1), 1-14.

Bruin, W. B., Taylor, L., Thomas, R. M., Shock, J. P., Zhutovsky, P., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., Assogna, F., Benedetti, F., Beucke, J. C., Boedhoe, P., Bollettini, I., Bose, A., Brem, S., Brennan, B. P., Buitelaar, J. K., Calvo, R., … van Wingen, G. A. (2020). Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters. Translational psychiatry, 10(1), 342.

Boedhoe, P., van Rooij, D., Hoogman, M., Twisk, J., Schmaal, L., Abe, Y., Alonso, P., Ameis, S. H., Anikin, A., Anticevic, A., Arango, C., Arnold, P. D., Asherson, P., Assogna, F., Auzias, G., Banaschewski, T., Baranov, A., Batistuzzo, M. C., Baumeister, S., Baur-Streubel, R., … van den Heuvel, O. A. (2020). Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups. The American journal of psychiatry, 177(9), 834–843.

Wang, F., Karipidis, I. I., Pleisch, G., Fraga-González, G., & Brem, S. (2020). Development of Print-Speech Integration in the Brain of Beginning Readers With Varying Reading Skills. Frontiers in human neuroscience, 14, 289.

Tijms, J., Fraga-González, G., Karipidis, I. I., & Brem, S. (2020). Editorial: The Role of Letter-Speech Sound Integration in Normal and Abnormal Reading Development. Frontiers in psychology, 11, 1441.

Kong, X. Z., Boedhoe, P., Abe, Y., Alonso, P., Ameis, S. H., Arnold, P. D., Assogna, F., Baker, J. T., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Brennan, B. P., Buitelaar, J., Calvo, R., Cheng, Y., Cho, K., Dallaspezia, S., … Francks, C. (2020). Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. Biological psychiatry, 87(12), 1022–1034.

Drechsler, R., Brem, S., Brandeis, D., Grünblatt, E., Berger, G., & Walitza, S. (2020). ADHD: Current Concepts and Treatments in Children and Adolescents. Neuropediatrics, 51(5), 315–335.

Mehringer, H., Fraga-González, G., Pleisch, G., Röthlisberger, M., Aepli, F., Keller, V., Karipidis, I. I., & Brem, S. (2020). (Swiss) GraphoLearn: an app-based tool to support beginning readers. Research and practice in technology enhanced learning, 15(1), 5.

Yun, J. Y., Boedhoe, P., Vriend, C., Jahanshad, N., Abe, Y., Ameis, S. H., Anticevic, A., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Calvo, A., Cheng, Y., Cho, K., Ciullo, V., Dallaspezia, S., Denys, D., … Kwon, J. S. (2020). Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium. Brain : a journal of neurology, 143(2), 684–700.



Pleisch, G., Karipidis, I.I., Brem, A., Röthlisberger, M., Roth, A., Brandeis, D., ..., Brem, S. (2019). Simultaneous EEG and fMRI reveals stronger sensitivity to orthographic strings in the left occipito-temporal cortex of typical versus poor beginning readers. Developmental Cognitive Neuroscience 40, 100717.

Willinger, D., Karipidis, I.I., Beltrani, S., Di Pietro, S., Sladky, R., Walitza, S., Stämpfli, P., Brem, S. (2019). Valence-dependent coupling of prefrontal-amygdala effective connectivity during facial affect processing. eNeuro 6(4).

Pleisch, G., Karipidis, I.I., Brauchli, Ch., Röthlisberger, M., Hofstetter, Ch., Stämpfli, P., Walitza, S. & Brem, S. (2019). Emerging neural specialization of the ventral occipitotemporal cortex to characters through phonological association learning in preschool children. NeuroImage 189(1):813-831.

Fraga-González, G., Smit, D.J.A., van der Molen, M.J.W., Tijms, J., de Geus, E.J.C. & van der Molen, M.W. (2019). Probability learning and feedback processing in dyslexia: A performance and heart rate analysis. Psychophysiology, 56(12), e13460.

Fraga-González, G., Karipidis, I.I. & Tijms, J. (2019). Reply to “Dyslexia: Still Not a Neurodevelopmental Disorder”. Brain sciences, 9(3),61.

Boedhoe, P.S.W., Alonso, P., Batistuda, M.C., Bose, A., Cho, K.Ik.K., Feusner, J.D. Gruner, P., Hu, H., Heymans, M.W., Ameis, S.H., Benedetti, F., Brem, S. et al. (2019). An Empirical Comparison of Meta- and Mega-Analysis With Data From the ENIGMA Obsessive-Compulsive Disorder Working Group. Frontiers in Neuroinformatics.

Kong, X.-Z., Boedhoe, P.S.W., ..., Francks, C. (2019). Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium. BiolPsych (2019).



Karipidis, I.I., Pleisch, G., Brandeis, D, Roth, A., Röthlisberger, M., Schneebeli, M., Walitza, S. & Brem, S. (2018). Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders. SCIENTIFIC Reports. 8:7121.

Kong, X.-Z., Mathias, S.R., Guadalupe, T. et al. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proceedings of the National Academy of Sciences of the United States of America 115(22):E5154-E5163.

Fraga-González, G., Karipidis, I.I. & Tijms, J. (2018). Dyslexia as a neurodevelopmental disorder and what makes it different from a chess disorder. Brain sciences, 8(10), 189.



Brem, S., Hunkeler, E., Mächler, M., Kronschnabel, J., Karipidis, I.I., Pleisch, G., Brandeis, D. (2017). Increasing expertise to a novel script modulates the visual N1 ERP in healthy adults. International Journal of Behavioral Development. 42 (3), p333-34.

Boedhoe, P.S.W., Schmaal, L., Abe, Y., Alonso, P., Ameis, S.H., M.Sc., Anticevic, A., Arnold, P.D., Batistuzzo, M.C., Benedetti, F., Beucke, J.C., Bollettini, I., Bose, A., Brem, S. et al. (2018). Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group. Am J Psychiatry 175(5):453-462.

Hauser T. U., Moutoussis, M., Iannaccone, R., Brem, S., Walitza, S., $Drechsler, R., Dayan, P., $Dolan, R. J. (2017). Increased decision thresholds enhance information gathering performance in juvenile Obsessive-Compulsive Disorder (OCD). PLoS Comput Biol 13(4):e1005440.

Hauser, T.U., Iannaccone, R., Dolan, J.R., Ball, J., Hättenschwiler, J., Drechlser, R., Rufer, M., Brandeis, D., $Walitza, S. & $Brem, S. (2017). Increased fronto-striatal reward prediction errors moderate learning in obsessive-compulsive disorder. Psychological Medicine 47(7):1246-1258.

Karipidis, I.I., Pleisch, G., Röthlisberger, M., Hofstetter, C., Dornbierer D., Stämpfli, P., Brem, S. (2017). Neural initialization of audiovisual integration in prereaders at varying risk for developmental dyslexia. Human Brain Mapping. 38(2):1038-1055.

Boedhoe, P.S.W., Schmaal, L., Abe, Y., Ameis, S., Arnold, P., Batistuzzo, M.C., Benedetti, F., Beucke, J., Bollettini, I., Bose, A., Brem, S., Calvo A. et al. (2017). Distinct subcortical volume alterations in pediatric and adult OCD: A worldwide meta- and mega-analysis. American Journal of Psychiatry 174(1):60-69.



Marino, M., Quanying, L., Brem, S., Wenderoth, N., Mantini, D. (2016). Automated detection and labelling of high-density EEG electrodes from structural MR images. Journal of Neural Engineering 13(5):056003.

Guadalupe, T., Mathias, S.R., van Erp, T.G.M., Whelan, C.D., Zwiers, M.P. et al.  (2016). Human brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging and Behaviour. 11(5):1497-1514.

Hauser, T.U., Rütsche, B., Wurmitzer, K., Brem, S., Ruff, C.C. & Grabner, R.H. (2016). Neurocognitive effects of transcranial direct current stimulation in arithmetic learning and performance: a simultaneous tDCS-fMRI study. Brain stimulation 9(6):850-858.



$1Hauser T.U., $1Hunt L., Iannaccone R., Walitza S., Brandeis D., $Brem S. & $Dolan R. (2015). Temporally dissociable contributions of human medial prefrontal subregions to reward-guided learning. J Neurosci. 35(32):11209-20.

Iannaccone, R., Hauser, T.U., Ball, J., Brandeis, D., Walitza, S. & Brem, S. (2015). Classifying adolescent attention-deficit/hyperactivity disorder (ADHD) based on functional and structural imaging. Eur Child Adolesc Psychiatry 24(10):1279-89.

Iannaccone, R., Hauser, T.U., Staempfli, P., Walitza, S., Brandeis, D. & Brem, S. (2015). Conflict Monitoring and Error Processing: New Insights from simultaneous EEG-fMRI.NeuroImage 105:395-407. 

Hauser, T.U., Iannaccone, R., Walitza, S., $Brandeis, D. & $Brem, S. (2015). Cognitive flexibility in adolescence: Neural and behavioral mechanisms of reward prediction error processing in adaptive decision making during development. NeuroImage 104:347-354.

Maurer, U., Brem, S., Liechti, M., Maurizio, S., Michels, L., Brandeis, D. (2015). Frontal Midline Theta Reflects Individual Task Performance in a Working Memory Task. Brain Topogr 28, 127–134 (2015).


Selected publications until 2015

Hauser, T.U., Iannaccone, R., Ball, J., Mathys, C., Brandeis, D., $Walitza, S. & $Brem, S. (2014). Role of the Medial Prefrontal Cortex in Impaired Decision Making in Juvenile Attention-Deficit/Hyperactivity Disorder. JAMA Psychiatry (formerly Arch Gen Psychiatry) 71(10):1165-1173.

Brem, S., Bach, S., Kujala, J.V., Maurer, U., Lyytinen, H., Richardson, U., Brandeis, D. (2013). An Electrophysiological Study of Print Processing in Kindergarten: The Contribution of the Visual N1 as a Predictor of Reading Outcome.Developmental Neuropsychology 38(8), 567-594.

Bach, S., Richardson, U., Brandeis, D., Martin, E. & Brem, S. (2013). Print-specific multimodal brain activation in kindergarten improves prediction of reading skills in second grade. Neuroimage 82:605-615.

Brem S., Bach S., Kucian K., Kujala J., Guttorm TK., Martin E., Lyytinen H., Brandeis D., Richardson U. (2010). Brain sensitivity to print emerges when children learn letter-speech sound correspondences.Proc Natl Acad Sci USA 107(17):7939-44.

Maurer, U., Bucher, K., Brem, S., Benz, R., Kranz, F., Schulz, E., van der Mark, S., Steinhausen, H. C. & Brandeis, D. (2009). Neurophysiology in preschool improves behavioral prediction of reading ability throughout primary school.Biol Psychiatry 66(4):341-8.

Maurer, U., Brem, S., Kranz, F., Bucher, K., Benz, R., Halder, P., Steinhausen, H.C. & Brandeis, D. (2007). Impaired tuning of a fast occipito-temporal response for print in dyslexic children learning to read. Brain 130(Pt 12):3200-10.

Maurer, U., Brem, S., Bucher, K. & Brandeis, D. (2005). Emerging neurophysiological specialization for letter strings. J Cogn Neurosci 17, 1532-1552.


$1First authors with equal contributions

$Senior authors with equal contributions

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Klinik für Kinder- und
Jugendpsychiatrie und Psychotherapie
Universität Zürich
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8032 Zürich

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